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KMID : 0381219820140030043
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Journal of RIMSK
1982 Volume.14 No. 3 p.43 ~ p.48
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Immunoperoxidase Study on the Production of Pregnancy-Spefific B1 glycoprotein (SP₁)
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Abstract
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Pregnancy-Specfic β1-glycoprotein (SP1), which is known that it is specifically detected only during the pregnancy, was derived from placental extracts by Bohn at 1971.
The characteristics of SP1 are not fully discovered upto now. But some of them have been clarified by some authors.
Such as its increasement according to gestation, abrupt disappearance after delivery, its relation with fetal weight, fetal sex and presence of twin pregnancies, and its decreased level in the serum of severe eclampsia patients.
By biochemical analysis, the placenta, i. e. syncytial trophoblast, vas confirmed as a synthetic site. But Park-and Kim ( 1980) postulated the possibility of fetal in situ production by immunofluorescent technique.
In order to confirm the possibility of fetal production of SP1. the author examined 10 curretted endometrial tissue containing chorionic villi and 20 tubes showing tubal gestation. After microscopic examination on the PAP-stained specimens. following results were ensued;
1) Syncytial trophoblasts represented most strong reaction to PAP staining for SP, among
the examined materials.
2) The fetal nucleated erythrocytes were sensitive tissue among examined fetal tissue to PAP staining.
3) Such findings were suggestive of the possibility of fetal de novo production of SP1.
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